{"id":84173,"date":"2023-12-22T15:45:15","date_gmt":"2023-12-22T14:45:15","guid":{"rendered":"https:\/\/intercoaching.fr\/decouverte-par-une-ia-les-premiers-nouveaux-antibiotiques-depuis-plus-de-60-ans\/"},"modified":"2023-12-22T15:45:15","modified_gmt":"2023-12-22T14:45:15","slug":"decouverte-par-une-ia-les-premiers-nouveaux-antibiotiques-depuis-plus-de-60-ans","status":"publish","type":"post","link":"https:\/\/intercoaching.fr\/en_au\/decouverte-par-une-ia-les-premiers-nouveaux-antibiotiques-depuis-plus-de-60-ans\/","title":{"rendered":"D\u00e9couverte par une IA : Les premiers nouveaux antibiotiques depuis plus de 60 ans"},"content":{"rendered":"<h2 class=\"wp-block-heading\">Nouvelle avanc\u00e9e gr\u00e2ce \u00e0 l\u2019IA : Une r\u00e9volution antibiotique<\/h2>\n\n\n<p>L\u2019intelligence artificielle (IA) r\u00e9volutionne actuellement divers champs, notamment celui de la sant\u00e9. La preuve en est avec l\u2019apparition d\u2019une classe in\u00e9dite d\u2019antibiotiques, mise au jour par cette technologie apr\u00e8s plus d\u2019une demie si\u00e8cle sans innovation majeure dans ce domaine.<\/p>\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n<div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Microbio - Classification des antibiotiques\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube-nocookie.com\/embed\/MXi_2MAJxUY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div>\n<\/figure>\n\n\n<h3 class=\"wp-block-heading\">Un pas de g\u00e9ant contre les bact\u00e9ries r\u00e9sistantes<\/h3>\n\n\n<p>Des mod\u00e8les d\u2019intelligence artificielle avanc\u00e9e ont ouvert la voie \u00e0 la d\u00e9tection d\u2019un agent novateur en mesure de combattre le \u00ab\u00a0Staphylococcus aureus\u00a0\u00bb multi-r\u00e9sistant (SARM), une souche bact\u00e9rienne responsable de plusieurs milliers de d\u00e9c\u00e8s annuels \u00e0 l\u2019\u00e9chelle mondiale. Cette perc\u00e9e pourrait \u00eatre d\u00e9terminante dans le combat contre la r\u00e9sistance grandissante aux antibiotiques existants.<\/p>\n\n\n<h2 class=\"wp-block-heading\">Pr\u00e9diction des mol\u00e9cules performantes<\/h2>\n\n\n<p>James Collins du MIT, coauteur de l\u2019\u00e9tude, explique que l\u2019objectif \u00e9tait de sonder la pertinence des mod\u00e8les d\u2019IA pour pr\u00e9dire l\u2019efficacit\u00e9 potentielle de certaines mol\u00e9cules comme antibiotiques. Ce cadre exp\u00e9rimental offre une m\u00e9thode plus \u00e9conomique et performante qui scrute la structure chimique des compos\u00e9s d\u2019une mani\u00e8re jusque-l\u00e0 in\u00e9dite.<\/p>\n\n\n<h3 class=\"wp-block-heading\">Des r\u00e9sultats prometteurs publi\u00e9s dans la revue \u00ab\u00a0Nature\u00a0\u00bb<\/h3>\n\n\n<p>Les conclusions de cette recherche sont dor\u00e9navant accessibles dans le journal scientifique \u00ab\u00a0Nature\u00a0\u00bb. L\u2019article r\u00e9sume le travail de 21 chercheurs qui ont contribu\u00e9 \u00e0 la r\u00e9alisation de cette \u00e9tude.<\/p>\n\n\n<h2 class=\"wp-block-heading\">Vers une meilleure compr\u00e9hension des mod\u00e8les d\u2019IA<\/h2>\n\n\n<p>Les scientifiques du MIT ont cherch\u00e9 \u00e0 \u00ab\u00a0ouvrir la bo\u00eete noire\u00a0\u00bb des r\u00e9seaux de neurones artificiels, utilis\u00e9s par l\u2019IA pour apprendre et g\u00e9n\u00e9rer des id\u00e9es innovantes. La d\u00e9marche adopt\u00e9e reposait sur un mod\u00e8le d\u2019apprentissage profond capable de pr\u00e9dire l\u2019efficacit\u00e9 antibact\u00e9rienne et la non-toxicit\u00e9 chez l\u2019humain.<\/p>\n\n\n<h3 class=\"wp-block-heading\">La m\u00e9thode de s\u00e9lection des compos\u00e9s<\/h3>\n\n\n<p>C\u2019est par un filtrage initial de quelque 39 000 substances pour leur action contre le SARM, suivi d\u2019une analyse d\u00e9taill\u00e9e de leurs structures chimiques, que l\u2019\u00e9quipe du MIT a pu nourrir son mod\u00e8le d\u2019IA. Felix Wong, chercheur au MIT, souligne l\u2019int\u00e9r\u00eat de d\u00e9mystifier les processus internes de ces mod\u00e8les.<\/p>\n\n\n<h2 class=\"wp-block-heading\">D\u00e9nicher un nouveau compos\u00e9 antimicrobien<\/h2>\n\n\n<p>Afin d\u2019affiner la s\u00e9lection, plusieurs mod\u00e8les d\u2019intelligence artificielle ont \u00e9t\u00e9 employ\u00e9s simultan\u00e9ment pour juger de la toxicit\u00e9 des mol\u00e9cules, par rapport \u00e0 trois diff\u00e9rents types de cellules humaines.<\/p>\n\n\n<p>Les algorithmes d\u2019IA ont scann\u00e9 pr\u00e8s de 12 millions de compos\u00e9s en vente libre, classant ainsi cinq familles de mol\u00e9cules prometteuses contre le SARM. Apr\u00e8s acquisition et test de pr\u00e8s de 280 de ces compos\u00e9s, deux candidats prometteurs ont \u00e9t\u00e9 identifi\u00e9s.<\/p>\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\"><p lang=\"fr\" dir=\"ltr\">[<a href=\"https:\/\/twitter.com\/hashtag\/Antibiotiques?src=hash&amp;ref_src=twsrc%5Etfw\">#Antibiotiques<\/a>] Augmentation pour la deuxi\u00e8me ann\u00e9e cons\u00e9cutive des prescriptions et de la consommation d\u2019antibiotiques en 2022 en ville<br>\u27a1\ufe0f\ud83d\udcc8 Soit une hausse de 16,6 % par rapport \u00e0 2021<br>\ud83d\udc49 Lire le communiqu\u00e9 <a href=\"https:\/\/t.co\/wrSCqhLk19\">https:\/\/t.co\/wrSCqhLk19<\/a> <a href=\"https:\/\/t.co\/R0SdMG8XUU\">pic.twitter.com\/R0SdMG8XUU<\/a><\/p>\u2014 Sant\u00e9publiqueFrance (@SantePubliqueFr) <a href=\"https:\/\/twitter.com\/SantePubliqueFr\/status\/1724098996120031448?ref_src=twsrc%5Etfw\">November 13, 2023<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n<h3 class=\"wp-block-heading\">Des tests positifs sur mod\u00e8les animaux<\/h3>\n\n\n<p>Des exp\u00e9rimentations chez la souris, visant \u00e0 simuler soit une infection cutan\u00e9e soit une infection syst\u00e9mique par le SARM, ont d\u00e9montr\u00e9 l\u2019efficacit\u00e9 de chacun des deux agents identifi\u00e9s, r\u00e9duisant de dix fois la quantit\u00e9 de bact\u00e9ries dans les organismes trait\u00e9s.<\/p>\n\n\n<p>En somme, gr\u00e2ce \u00e0 l\u2019application des mod\u00e8les d\u2019intelligence artificielle dans le domaine pharmaceutique, une nouvelle \u00e8re s\u2019annonce peut-\u00eatre pour la recherche et la mise au point d\u2019antibiotiques en mesure de d\u00e9jouer les strat\u00e9gies d\u2019\u00e9vasion des bact\u00e9ries r\u00e9sistantes.<\/p>\n\n\n<div class=\"kk-star-ratings kksr-auto kksr-align-right kksr-valign-bottom\"\n    data-payload='{&quot;align&quot;:&quot;right&quot;,&quot;id&quot;:&quot;84173&quot;,&quot;slug&quot;:&quot;default&quot;,&quot;valign&quot;:&quot;bottom&quot;,&quot;ignore&quot;:&quot;&quot;,&quot;reference&quot;:&quot;auto&quot;,&quot;class&quot;:&quot;&quot;,&quot;count&quot;:&quot;0&quot;,&quot;legendonly&quot;:&quot;&quot;,&quot;readonly&quot;:&quot;&quot;,&quot;score&quot;:&quot;0&quot;,&quot;starsonly&quot;:&quot;&quot;,&quot;best&quot;:&quot;5&quot;,&quot;gap&quot;:&quot;5&quot;,&quot;greet&quot;:&quot;Notez cet article&quot;,&quot;legend&quot;:&quot;0\\\/5 - (0 votes)&quot;,&quot;size&quot;:&quot;24&quot;,&quot;title&quot;:&quot;D\u00e9couverte par une IA : Les premiers nouveaux antibiotiques depuis plus de 60 ans&quot;,&quot;width&quot;:&quot;0&quot;,&quot;_legend&quot;:&quot;{score}\\\/{best} - ({count} {votes})&quot;,&quot;font_factor&quot;:&quot;1.25&quot;}'>\n            \n<div class=\"kksr-stars\">\n    \n<div class=\"kksr-stars-inactive\">\n            <div class=\"kksr-star\" data-star=\"1\" style=\"padding-right: 5px\">\n            \n\n<div class=\"kksr-icon\" style=\"width: 24px; 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